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2 edition of Formation of a cartilage-biomaterial biphasic construct with a calcified cartilage zone. found in the catalog.

Formation of a cartilage-biomaterial biphasic construct with a calcified cartilage zone.

Katherine Sarah Allan

Formation of a cartilage-biomaterial biphasic construct with a calcified cartilage zone.

by Katherine Sarah Allan

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  • 24 Currently reading

Published .
Written in English


About the Edition

This study describes the development of a biphasic construct in which the hyaline cartilage has calcified cartilage close to the tissue-substrate interface. The mineral that formed in vitro was identified as hydroxyapatite and was similar to that found in vivo. The inclusion of mineralized cartilage within the extracellular matrix significantly improved the load-bearing capacity, tissue stiffness and attachment to the underlying substrate when compared to cartilage lacking a mineralized component. Understanding the mechanical properties of the cartilage-bone interface will provide valuable insight into the necessary conditions for forming suitable biphasic constructs in vitro that can be used to successfully resurface osteochondral defects.

The Physical Object
Pagination129 leaves.
Number of Pages129
ID Numbers
Open LibraryOL19215161M
ISBN 100494022566

horse have shown a tendency for articular calcified cartilage (ACC) to crack more or less perpendicular to its mineralising front, parallel to the fi bres forming the main component of the cartilage collagen (Boyde et al., ). In addition, cracks within ACC and subchondral bone (SCB) become repaired by the intercalation of a matrix.   Allan K, Pilliar R, Wang J, et al. Formation of biphasic constructs containing cartilage with a calcified zone interface. Tissue Eng. ;– PubMed CrossRef Google ScholarCited by: 2.

Formation of biphasic constructs containing cartilage with a calcified zone interface. Tissue Eng. ; 13 (1)– doi: /ten [ PubMed ] [ Cross Ref ]Cited by:   1. Introduction. Although cartilage repair has been studied for many years, the regeneration mechanism is still poorly understood, and the quality of repaired cartilage is far from satisfaction and functional restoration [1, 2].Increasing evidences show that cartilage regeneration is not only tissue engineering trielements related, but other mechanisms (such as oxygen gradient, Cited by:

ZCC - zone of calcified cartilage. Looking for abbreviations of ZCC? It is zone of calcified cartilage. zone of calcified cartilage listed as ZCC. Zone of calcified cartilage - How is zone of calcified cartilage abbreviated? zone of calcified cartilage; Zone of Cartilage Resorption; zone of cementation; zone of chondrocyte hypertrophy; zone. Cartilage cells enlarge (hypertrophy) and die because of the calcium salt deposits. This causes holes in the matrix. Blood vessels then deposit osteoblasts, osteoprogenitor cells, osteoclasts, and primitive marrow cells into the matrix holes. Osteoblasts lay down bone from calcified cartilage. Future growth occurs in the zone of proliferation.


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Formation of a cartilage-biomaterial biphasic construct with a calcified cartilage zone by Katherine Sarah Allan Download PDF EPUB FB2

Formation of Biphasic Constructs Containing Cartilage with a Calcified Zone Interface K.S. ALLAN, MASc,1 R.M. PILLIAR, Ph.D.,2 J. WANG, Ph.D.,2 M.D. GRYNPAS, Ph.D.,1. In conclusion, developing a biphasic construct with a calcified zone at the tissue–biomaterial interface resulted in significantly better cartilage load-bearing (compressive) properties and interfacial shear strength, emphasizing the importance of the presence of a mineralized zone in bioengineered by: Formation of Biphasic Constructs Containing Cartilage with a Calcified Zone Interface Article (PDF Available) in Tissue Engineering 13(1) February with Reads How we measure 'reads'.

Healthy cartilage tissue interfaces with bone in vivo through a zone of calcified cartilage (ZCC), which enhances mechanical integration by redistributing forces acting at the interface 9.

BMSCs are suitable for creating calcified cartilage, because they can be differentiated to produce cartilage tissues that mineralize their matrix Cited by: In Vitro Calcification of Immature Bovine Articular Cartilage Article (PDF Available) in Cartilage 1(4) October with 50 Reads How we measure 'reads'.

The superficial zone of normal cartilage has inhibitory effect on deep cartilage mineralization by paracrine, and tidemark duplication is resulted from the termination of inhibitory mechanism of calcium salt deposition. Therefore, it hints that a relatively intact cartilage in OA still has inhibitory mechanism towards tidemarks only it is Cited by: 5.

Objective: The initial attachment of transplanted chondrocytes to the surface of a cartilage defect is crucial for the success of chondrocyte transplantation. The purpose of this study was to investigate the early interaction of chondrocytes with the deep or calcified zones of cartilage or the subchondral bone, joint surfaces to which transplanted chondrocytes might have to attach in by: S41 $42 C.

Buckland-Wright and N. Pateh Calcified cartilage zone in OA Fig. Part of the macroradiographs of metacarpophalangeal and distal interphalangeal joints of a patient with OA showing the advancement of the zone of calcified cartilage at the convex articular surfaces (arrow heads) extending into the articular by: 8.

Calcified cartilage zone (CCZ) is a thin interlayer of hard tissue, between the hyaline articular cartilage and the subchondral bone 1. Hyaline cartilage is attached to the subchondral bone by this highly mineralized zone. Mechanical stress and biological stimuli are transmitted from the hyaline cartilage to the subchondral bone through by: Highly hydrated, aneural, devoid of blood or lymphatic vessels, articular cartilage is the connective tissue covering the epiphyseal surface of the articulating a material point of view, two phases can be recognised within the articular cartilage.First, a solid phase composed of collagen, mainly of type II, is present as a network of fibres responsible for the overall shape of Cited by: Introduction.

Tissue engineering is an interdisciplinary field dedicated to the regeneration of functional human tissues. Despite the body having intrinsic self-healing properties, the extent of repair varies amongst different tissues, and may also be undermined by the severity of injury or disease.

48 The classic paradigm relies on a combination of biomaterial scaffolds, cells, and bioactive Cited by: must be first understood [1]. Biphasic and triphasic models developed by Mow and coworkers relate AC structure with its mechanical behavior and provided researchers with valuable models for AC biomechanics [2, 3].

Although much is known about AC and its mechanical properties, the zone of calcified cartilage (ZCC) has been sparsely studied. Engineering cartilage tissue with zonal properties as close as possible to construct formation.

Any sign of vascular invasion or lacunar characteristics of typical calcified cartilage. Allan et al. found in that the formation of biphasic constructs containing cartilage and designed with a calcified zone interface resulted in better cartilage load-bearing properties and interfacial shear strength.

However, this study also demonstrated failure due to shear at the cartilage–calcium–polyphosphate interface, indicating Cited by: 1.

- calcified cartilage & old bone resorbed by OCs to make medullary cavity --> makes bony diaphysis Endochondral Ossification 4&5: Postnatal Development - cartilage grows interstitially, calcifies, & replaced by bone at metaphysis.

The concept of biphasic or multi-layered compound scaffolds has been explored within numerous studies in the context of cartilage and osteochondral regeneration. To date, no system has been identified that stands out in terms of superior chondrogenesis, osteogenesis or the formation of a zone of calcified cartilage (ZCC).

Herein we present a 3D plotted scaffold, comprising an alginate and Cited by: The results show that this biphasic scaffold can support cartilage formation on a calcium-phosphate surface in a double-chamber bioreactor, and it seems reasonable to suggest that there is. Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called is synonymous with bone tissue formation.

There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue (), while endochondral ossification.

The calcified zone is the transitional zone that exists in between the articular cartilage and the subchondral bone. It consists of few chondrocytes embedded in a calcified extracellular matrix.

This zone contains collagen type X, unlike collagen type II in the other zones, which helps with cartilage mineralization and provides structural integrity. Importantly, cartilage defects without bone damage occur much more frequently than osteochondral lesions and no biomaterial-based solutions have been developed so far to induce a proper zonal architecture into a non-mineralized hyaline cartilage layer and a calcified cartilage bottom zone.

All available biphasic constructs with bone replacement Cited by: 3. Fracture healing. During fracture healing, cartilage is often formed and is called cartilage ultimately develops into new bone tissue through the process of endochondral ossification.

Recently it has been shown that biomimetic bone like apatite inhibits formation of bone through endochondral ossification pathway via hyperstimulation of extracellular calcium sensing receptor (CaSR).2) Formation of a bony callus - occurs both internal and external at the fracture site.

Fibrous connective tissue and hyaline cartilage formed. Endochondral bone formation replaces the cartilage with primary bone. Intramembranous bone formation also produces primary bone in area. Primary bone resorbed and replaced by secondary bone.The formation of an adequate connection between engineered cartilage and biomaterial is not established in vitro until now, mainly, because the cartilage-carrier interface has to withstand high shear stress when implanted in the joint.

It is known that several properties of the biomaterial have an impact on anchorage and tissue by: 5.